Health Library · Medications

Zoloft / Lexapro side effects

Overview

Sertraline (Zoloft) and escitalopram (Lexapro) are the two most-prescribed SSRIs. Both effective; slight differences in profile.

Symptoms to watch for

  • First 2 weeks: nausea, headache, GI upset, activation
  • Long-term: sexual dysfunction, sweating, weight changes, apathy
  • Discontinuation syndrome if stopped abruptly

Treatment

Start low, take with food, allow 4–6 weeks for full effect. Bupropion added if sexual side effects. Slow taper when stopping.

When to book a visit

Book to start, adjust, or switch antidepressants.

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