Overview
Depression is more than sadness — it's a persistent low mood plus loss of interest, energy, sleep, and self-worth that lasts at least 2 weeks and impairs function. It's medical and highly treatable.
Symptoms to watch for
- Persistent sad, empty, or hopeless mood
- Loss of interest in things you usually enjoy
- Fatigue and low energy
- Sleep changes (too much or too little)
- Appetite or weight changes
- Difficulty concentrating
- Feelings of worthlessness or guilt
- Thoughts of death or suicide
What else could this be?
- Hypothyroidism
- Vitamin D or B12 deficiency
- Anemia
- Sleep apnea
- Grief (normal after loss)
- Bipolar depression (screen for prior mania)
How it's diagnosed
PHQ-9 questionnaire plus clinical interview. Labs to rule out mimics: TSH, CBC, vitamin D, B12.
Treatment
First-line: SSRIs (sertraline, escitalopram) or SNRIs (venlafaxine, duloxetine). Bupropion is a good option for low energy or sexual side effect concerns. Therapy (CBT, IPT) has equal evidence. Combination is best for moderate–severe depression.
When to book a visit
Book if symptoms have lasted 2+ weeks or you're struggling to function. Call 988 for a crisis.
Book online todayFrequently asked
How long until antidepressants work?
2–4 weeks for early effects, 6–8 weeks for full benefit. Side effects usually settle within 2 weeks.
Can Clindle prescribe antidepressants online?
Yes — a licensed clinician can evaluate, prescribe, and manage follow-up entirely by video.